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You can learn more about general Designation information here.

Character designations carry certain inherent traits along with them. These traits are encoded in a particular eight-digit binary code known as Designation Natural Abilities, or DNA. The first four digits pertain to Attributes (Agility, Intelligence, Resilience, Perception) and the second four digits correspond to Skill classes (Combat, Modding, Streetwise, Infiltration). For example, the Modder DNA looks like the following.

AgiIntResPerComModStrInf
01100100
Modder DNA

Where an Attribute or Skill has a 1, it automatically has an ability point assigned to one of its slots. If it has a 0, it does not obtain any natural points.

Humans

Humans get an Agility or Resilience bonus.

DesignationAttributesSkills
Modders 01100100
Runners 10100010
Tracers10000011
Vigilantes10011000
Hustlers 00101100
Execs 01100001
Vanguards10101000
Shamans10010010
Human Designation Natural Abilities (DNA) Strains

Cogitos

Cogs get an Intelligence or Perception bonus.

DesignationAttributesSkills
Classifiers00011010
Recommenders01000101
Generative01001100
Predictive00010011
Cogito Designation Natural Abilities (DNA) Strains